Current research interests

Nedelcu AM. 2011. On the evolution of self during the transition to multicellularity.  In Carlos Lopez-Larrea (ed) “Self and Non-self”. Landes Biosciences (in press).

Nedelcu AM and RE Michod. 2004. Evolvability, modularity, and individuality during the transition to multicellularity in volvocalean green algae. In Schlosser G and Wagner G (eds) “Modularity in development and evolution”. pp. 468-489. University of Chicago Press; download pdf here

Michod RE and AM Nedelcu.  2004.  Cooperation and conflict during the unicellular-multicellular and prokaryotic-eukaryotic transitions.  In Moya A and Font E (eds) “Evolution: From Molecules to Ecosystems”. pp. 195-208. Oxford University Press; download reprint here.

Michod RE and AM Nedelcu.  2003. On the reorganization of fitness during evolutionary transitions in individuality. Integrative and Comparative Biology 43:64-73; download reprint here.

Michod RE, AM Nedelcu, and D Roze.  2003. Cooperation and conflict in the evolution of individuality. IV. Conflict mediation and evolvability in Volvox carteri.  BioSystems. 69:95-114; download reprint here. 

Nedelcu AM and  RE Michod.  2011. Molecular mechanisms of life history trade-offs and the evolution of multicellular complexity in volvocalean green algae. In Flatt T and Heyland A (eds). “Mechanisms of Life History Evolution: The Genetics and Physiology of Life History Traits and Trade-Offs”. pp. 271-283. Oxford University Press.

Prochnik SE, Umen J, Nedelcu AM et al. 2010. Genomic analysis of organismal complexity in the multicellular green alga Volvox carteri. Science 329:223-226.

Nedelcu AM. 2009. Environmentally-induced responses co-opted for reproductive altruism. Biology Letters 5: 805-808.

Nedelcu AM, Driscoll WW, Durand PM, Herron M, and Rashidi E. 2011. On the paradigm of adaptive suicide in the unicellular world. Evolution 65:3-20.

Nedelcu AM. 2009.  Comparative genomics of phylogenetically diverse unicellular eukaryotes provide new insights into the genetic basis for the evolution of the programmed cell death machinery. Journal of Molecular Evolution 68: 256-268.

Nedelcu AM. 2006. Evidence for p53-like-mediated stress responses in green algae. FEBS Letters 580:3013-3017

Sprouffske K, Aktipis CA,  Radich JP, Carroll M, Nedelcu AM, and Maley CC. An evolutionary explanation for the presence of cancer non-stem cells in neoplasms (submitted).

Nedelcu AM and Caulin A. 2011. The evolution of cancer suppressor mechanisms. In Maley C (ed) "Frontiers of Evolution in Cancer". Springer (submitted).

Nedelcu AM and C. Tan. 2007. Early diversification and complex evolutionary history of the p53 tumor suppressor gene family. Development Genes and Evolution  217: 801-806.

Michod RE., Bernstein H, Nedelcu AM. 2008. Adaptive Value of Sex in Microbial Pathogens. Infection, Genetics and Evolution  8: 267-285.

Nedelcu AM. 2005. Sex as a response to oxidative stress: Stress genes co-opted for sex. Proceedings of Royal Society London B, Biological Sciences 272: 1935-1940

Nedelcu AM, Marcu O, and RE Michod. 2004. Sex as a response to oxidative stress: A two-fold increase in cellular reactive oxygen species activates sex genes. Proceedings of Royal Society London B, Biological Sciences 271: 1591-1596; download pdf here

Nedelcu AM and RE Michod. 2003.  Sex as a response to oxidative stress: The effect of antioxidants on sexual induction in a facultatively sexual lineage. Proc. Royal Society London B, Biological Sciences 270: S136-S139; download reprint here.

Nedelcu AM, A Blakney and K Logue. 2009. Functional replacement of a primary metabolic pathway via multiple independent eukaryote-to-eukaryote gene transfers and selective retention. Journal of Evolutionary Biology 22: 1882-1894

Nedelcu AM, I Miles, K Karol, A Fagir. 2008. Adaptive eukaryote-to eukaryote gene transfer: Stress-related genes of algal origin in the closest unicellular relatives of animals. Journal of Evolutionary Biology 21: 1852-1860